Its effects might last longer if you have mild to moderate ED. John’s wort. How should this medicine be used? A newer form of the medicine that dissolves on the tongue might work faster than the pill that you swallow. If you are taking the rapidly disintegrating tablet, check the blister pack before you take your first dose.Vardenafil. These medicines are called PDE5 inhibitors. They enhance the effects of a chemical the body makes that relaxes muscles in the penis, called nitric oxide. This boosts blood flow and helps you get an erection from sexual activity. How oral medicines differ Each oral medicine for ED has a slightly different chemical makeup. Vardenafil is a medication that treats erectile dysfunction. ED is the inability to achieve and sustain an erection suitable for sexual intercourse. This medication works by increasing blood flow to your penis, which helps you maintain an erection. What is this medication? VARDENAFIL (var DEN a fil) treats erectile dysfunction (ED). Vardenafil can typically work to help an erection occur and last longer for anywhere between. In one study, people who took vardenafil reported that it worked for up to after taking a dose. If your erection lasts for longer than .