If the headaches continue, let your doctor know If you experience any other symptoms which you think may be due to the tablets and which you are concerned about, speak with your doctor or pharmacist for advice. Do not take more than one tablet in any 24 hours. Patients should be advised not to use Priligy in combination with alcohol. These changes are not clinically significant. It is recommended that tablets be taken with at least one full glass of water. Recreational drugs with serotonergic activity such as ketamine, methylenedioxy methamphetamine MDMA and lysergic acid diethylamide LSD may lead to potentially serious reactions if combined with Priligy. Patient-reported outcome-defined level of clinical benefit Three of the RCTs in Table 3 also reported a predefined composite clinical outcome as a measure of clinical benefit following dapoxetine treatment.Dapoxetine is a short-acting selective serotonin re-uptake inhibitor. Indications and dose. Dapoxetine (Priligy TM, Johnson and Johnson, Raritan, NJ) is the first and only product licensed for the treatment of premature ejaculation (PE) in men aged 18–64 years. At present, dapoxetine is licensed in ten countries, including several countries in Europe, and Mexico, South Korea, and New Zealand. 1, 2 PE is the most common . This medication is used to treat premature ejaculation. It increases time to ejaculate, and thus reduces the stress you face over how fast you ejaculate and may improve your satisfaction during sexual intercourse.