Animal and human sexual psychopharmacological studies have demonstrated that serotonin 5-hydroxy-tryptamine, 5-HT and 5-HT receptors are involved in ejaculation and confirm a role for selective serotonin reuptake inhibitors SSRIs in the treatment of PE [ Olivier et al. Ghaffar Alan D. The primary mechanism of action of SSRIs is to inhibit the presynaptic reuptake of serotonin at the serotonin transporter, subsequently increasing serotonin at the postsynaptic membrane in the serotonergic synapse [ 8 ]. Personal distress related to ejaculation Five studies in Table 2 report changes from baseline in personal distress related to ejaculation, ie, two integrated analyses and three RCTs. Are you also having trouble getting and keeping an erection erectile dysfunction? Among the SSRIs, fluoxetine exhibits the least specific binding to SERT and, at high doses, can increase synaptic norepinephrine and dopamine levels [ 64 ]. Preparing for your appointment It’s typical to feel embarrassed when talking about sexual problems.rows · Background Dapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation. In a phase II proof-of-concept study conducted by . Dapoxetine is a potent SSRI which is administered on demand 1–3 h prior to planned sexual contact. It is rapidly absorbed and eliminated, resulting in minimal accumulation, . Dapoxetine is a short-acting SSRI developed specifically for the treatment of PE. Early trials with dapoxetine have documented successful outcomes without serious .