Refills: See if you can set up automatic refills or order as needed. Your doctor will help you decide the best time for you to take tadalafil before sexual activity. Furthermore, the longer half-life is the basis for tadalafil’s daily therapeutic use in treating pulmonary arterial hypertension. Do not take a double dose or more than one dose per day to make up for a missed one. Tadalafil is sometimes taken as needed, usually at least 30 minutes before sexual activity and not more often than once every 24 hours. You can see an in-person provider or speak with a doctor virtually. It may be taken with or without food.The recommended starting dose for Cialis intended for once daily use is mg, take at the same time each day, without regard to timing of sexual activity. This may be increased to 5mg/day based on need and tolerability. May be taken with or without food. Cialis is available as a generic, under the name tadalafil. 3. Both treatment options are available in doses of 5, 10, and 20 mg. The costs are: Cialis: A prescription of 30 Cialis pills costs $ Tadalafil: 30 tadalafil pills are available for $ The Cialis cost with insurance depends on your plan and benefits. For example, the cost may vary based on whether you have to pay a part of the cost or whether you have a set copay.